Baccile Research Group
4. McBee, D.P.; Hulsey, Z.N.; Hedges, M.R.; Baccile, J.A.*; Biological Demands and Toxicity of Isoprenoid Precursors in Bacillus Subtilis Through Cell-Permeant Analogs of Isopentenyl Pyrophosphate and Dimethylallyl Pyrophosphate. ChemBioChem, 2024, e202400064. [doi]
3. Rossi, F.M.#; McBee, D.P.#; Trybala, T.N.; Ganzalez Curbelo, C.; Mazur, W.; Baccile, J.A.*; Membrane permeant analogs for independent cellular introduction of the terpene precursors isopentenyl- and dimethylallyl-pyrophosphate. ChemBioChem, 2023, 24, e202200512. [doi]
2. Lou, J.; Qualls, M.L.; Hudson, M.M.; McBee, D.P.; Baccile, J.A.; Best, M.D.*; Reactive Oxygen Species (ROS) Activated Liposomal Cell Delivery using a Boronate-Caged Guanidine Lipid. Chem. Eur. J . 2022, e202201057. [doi]
1. Qualls, M.L.; Lou, J.; McBee, D.P.; Baccile, J.A.; Best, M.D.*; Cyclic Disulfide Liposomes for Membrane Functionalization and Cellular Delivery. Chem. Eur. J . 2022, e202201164. [doi]
Josh’s Postdoctoral Research
#Equal contribution *Correspondence
19. Rapp, P.B.*; Baccile, J.A.; Galimidi, R.P.; Vielmetter, J.; Engineering antigen-specific tolerance to an artificial protein hydrogel. ACS Biomater. Sci. Eng. 2024, 10, 4, 2188-2199. [doi] For original bioRxiv. [doi]
18. Baccile, J.A.; Voorhees, P.J.; Chillo, A.J.; Berry, M.; Morgenstern, R.; Schwertfeger, T.J.; Rossi, F.M.*; Nelson, C.D.S.* ; Site-Specific Small Molecule Labeling of an Internal Loop in JC Polyomavirus Pentamers Using the π-Clamp Mediated Cysteine Conjugation. Chembiochem, 2021, 22; 1-6. [doi] – Cover feature
Josh’s Graduate Research
#Equal contribution *Correspondence
17. Hoki, S.S.; Le, H.H.; Mellott, K.E.; Zhang, Y.K.; Fox, B.W.; Rodrigues, P.R.; Yu, Y.; Helf, M.J.; Baccile, J.A.#*; Schroeder, F.C.#*; Deep Interrogation of Metabolism Using a Pathway-Targeted Click-Chemistry Approach. J. Am. Chem. Soc. 2020, 142(43); 18449-18459. [doi]
16. Baccile, J.A.; Le, H.H; Pfannenstiel, B.T.; Bok, J.W.; Gomez, C.; Brandenburger, E.; Hoffmeister, D.; Keller, N.P.*; Schroeder, F.C.*; Diketopiperazine Formation in Gliotoxin Biosynthesis Requires Dedicated Cyclization and Thiolation Domains. Angew. Chem. Int. Ed. 2019, 58, 1-6. [doi]
15. O’Neill, E.M.; Mucyn, T.S.; Patteson, J.B.; Finkel, O.M.; Chung, E.H.; Baccile, J.A.; Massolo, E.; Schroeder, F.C.; Dangl, J.L.; Li, B.*; Phevamine A, a Small Molecule that Suppresses Plant Immune Responses. 2018, Proc. Natl. Acad. Sci. USA. 115, E9514-9522. [doi]
14. Spraker, J.E.; Weimann, P.; Baccile, J.A.; Venkatesh, N.; Schumacher, J.; Schroeder, F.C.; Sanchez, L.M.; Keller, N.P.*; Conserved Responses in a War of Small Molecules between a Plant-Pathogenic Bacterium and Fungi. 2018, mBio (3), e00820-18. [doi]
13. Meyer, J.M.; Bose, N.; Artyukhin, A.B.; Rodelsperger, C.; Markov, G.V.; Yim, J.J.: Grimm, D.; Claassen, M.; Panda, O.; Baccile, J.A.; Jolic, D.; Schroeder, F.C.*; Sommer, R.J.*; Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis. 2018, Cell Chem. Biol. 25, 787-796. [doi]
12. Lim, F.Y.; Won, T.H.; Baccile, J.A.; Wisecaver, J.; Rokas, A.; Schroeder, F.C.*; Keller, N.P.*; Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus. 2018, mBio (3), e00785-18.[doi]
11. #Khalid, S.; #Baccile, J.A.; #Spraker, J.E.; Bok, J.W.; Velk, T.A.; Imran, M.; Schroeder, F.C.; Keller, N.P.*; NRPS-derived isoquinolines and lipopeptides mediate antagonism between plant pathogenic fungi and bacteria. 2017, ACS Chem. Biol. 13, 171-179. [doi]
10. Liberti, M.V.; Wardell, S.E.; Ziwei, D.; Baccile, J.A.; Liu, X.; Gao, X.; Baldi, R.; Madhukar, N.S.; Mehrmohamadi, M.; Shestov, A.A.; Elemento, O.; Schroeder, F.C.; McDonnell, D.P.; Locasale, J.W.*; A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product. 2017, Cell Metab. 26, 648-659. [doi]
9. #Hind, S.R.; #Hoki, J.S.; Baccile, J.A.; Boycle, P.C.; Schroeder, F.C.*; Martin, G.B.*; Detecting the interaction of peptide ligands with plant membrane receptors. 2017, Curr. Protoc. Plant Biol. 2, 240-269. [doi]
8. McClure, R.A.; Goering, A.W.; Ju, K.S.; Baccile, J.A.; Schroeder, F.C.; Metcalf, W.W.; Thomson, R.J.; Kelleher, N.L.*; Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations. 2016, ACS Chem Biol. 11, 3452-3460. [doi]
7. #Baccile, J.A.; #Spraker, J.E.; Le, H.H.; Brandenburger, E.; Gomez, C.; Bok, J.W.; Macheleidt, J.; Brakhage, A.A.; Hoffmeister, D.; Keller, N.P.*; Schroeder, F.C.*; Plant-like isoquinoline biosynthesis in fungi. Nat. Chem. Biol. 2016, 12, 419-424. [doi]
- Featured in C&E News, “Fungi make isoquinolines” [link]
6. Hind, S.R.; Strickler, S.R.; Boycle, P.C.; Bao, Z.; O’Doherty, I.M.; Baccile, J.A.; Dunham, D.M.; Viox, E.G.; Clarke, C.R.; Vinatzer, B.A.; Schroeder, F.C.; Martin, G.B.*; Tomato receptor FLAGELLIN-SENSING 3 perceived flagellin and confers disease resistance. Nat. Plants. 2016, 2, Article number 16128. [doi]
5. Wever, W.J.; Bogart, J.W.; Baccile, J.A.; Chan, A.N.; Schroeder, F.C.; Bowers, A.A.*; Chemoenzymatic Synthesis of Thiazolyl Peptide Natural Products Featuring an Enzyme-Catalyzed Formal [4+2] Cycloaddition. J. Am. Chem. Soc. 2015, 137, 3494-3497. [doi]
4. Macheleidt, J.; Scherlach, K.; Neuwirth, T.; Schmidt-Heck, W.; Straßburger, M.; Spraker, J.; Baccile, J. A.; Schroeder, F. C.; Keller, N. P.; Hertweck, C.; Heinekamp, T. and Brakhage, A. A.*; Transcriptome analysis of cyclic AMP-dependent protein kinase A–regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus. Molecular Microbiology, 2015, 96,148–162. [doi]
3. Wiemann, P.; Lechner, B.E.; Baccile, J.A.; Velk, T.A.; Yin, W-B; Bok, J.W.; Pakala, S.; Losada, L.; Nierman, W.C.; Schroeder, F.C.; Haas, H.; Keller, N.P.*; Perturbations in small molecule synthesis uncovers an iron-responsive secondary metabolite network in Aspergillus fumigatus. Front. Microbiol. 2014, 5, 530. [doi]
2. #Yin, W.; #Baccile, J.A.; Bok, J.W.; Chen, Y.; Keller, N.P.; Schroeder, F.C.; A Nonribosomal Peptide Synthetase-Derived Iron(III) Complex from the Pathogenic Fungus Aspergillus fumigatus. J. Am. Chem. Soc. 2013, 135, 2064-2067. [doi]
Josh’s Undergraduate Research
1. Baccile, J.A.; Morrell, M.A.; Falotico, R.M; Milliken, B.T.; Drew, D.L.; Rossi, F.M.; Modular synthesis of photocleavable peptides using click chemistry. Tetrahedron Lett.2012, 53, 1933-1935. [doi]